Abstract from Original Article on WIlson's Disease : Face of Giant Panda sign.
Ref : http://jnnp.bmj.com/content/54/7/624.full.pdf+html
"The superior colliculus, which in normal subjects shows the same signal intensity as cerebral white matter, showed a remarkable decrease in signal intensity in the patients with Wilson's disease. A reversal of signal intensity' was seen in the lateral portion of the substantia nigra, that is, the marked hypointensity chracteristic of the normal substantia nigra, was lost in cases 1 and 2. In these patients, it showed almost the same signal
level as cerebral white matter; case 3 showed a normal hypo-intensity in that area. The thalamus and the tegmentum of the mid-brain showed a marked hyper-intensity, especially around the red nucleus, which retained their normal hypo-intensity. As a result, the T2- weighted horizontal section of the mid-brain in these patients showed the "face of giant panda" appearance, which we describe for the first time and is specific for Wilson's disease."
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