Extrahepatic metastasis of hepatocellular carcinoma Part 1

Extrahepatic metastasis of hepatocellular carcinoma: incidence and risk factors.

REFERENCE from PUBMED

RESULTS:
During the average observation period of 3.9 years, extrahepatic metastasis was diagnosed in 123 in the treatment-naïve and 53 in the patients treated previously. The incidence rate of extrahepatic metastasis, as detected during the lifetime after medical treatment of HCC, was approximately 13% at 5 years.

Multivariate analysis with Cox proportional hazard model revealed that positivity for viral markers, larger tumour diameter, multiple tumour nodules, presence of vascular tumour invasion and elevated tumour markers were associated with the development of extrahepatic metastasis.

CONCLUSION:
The incidence of extrahepatic metastasis of HCC diagnosed during clinical course was not frequent. Advanced intrahepatic lesions, presence of vascular tumour invasion, elevated tumour markers and presence of viral hepatitis were risk factors for extrahepatic metastasis.